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The Food and Drug Administration, FDA, has approved the drug Vivitrol to the treatment of opioid dependence according to a news release by them on 10-12-2010.

Using two separate drugs to shed weight can be very effective you'll find combinations in front of the FDA now awaiting approval. When dealing with weight loss and the those who go through it you need to err assisting caution and let the FDA do its job and demand some research be done so the public understands the side effects and dangers of the medications before we take them. Keep in mind that drug companies come in business to generate income and that they would say almost anything to keep people on their medications.

Researchers discovered that participants investing in this drug for any year, dropped excess weight within one month and have kept the extra weight off throughout the 56 weeks in the study. Contrave is often a combination of the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which can be made up of many active ingredient, which can make them more efficient and safer.

Combo-pilling could be the newest fad or better yet the newest into the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is now popular may be the fact that as of right now there are not any long term prescription slimming capsules that have been approved by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be licensed by the FDA.

Seizures are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug may also raise blood pressure and heart rate, and mustn't be used in people with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure level and heartrate and must not used in patients with uncontrolled high hypertension, in addition to by you aren't heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients with a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert medical professionals and patients for the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking.


Suboxone includes two drugs; buprenorphine and naloxone. The naloxone is irrelevant in the event the addict uses the medication properly, but in the event the tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone is utilized correctly, the naloxone is destroyed in the liver after that uptake in the intestines and contains no therapeutic effect. Buprenorphine may be the active substance; it's absorbed within the tongue (and during the entire mouth) but destroyed by the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I manipulate this formulation once the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I also have treated addicts who've had gastric bypass, the location where the first the main intestine is bypassed as well as the stomach contents empty into a more distal section of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the procedure with normal anatomy in which the drug is taken up through the duodenum and transferred directly to the liver by the portal vein, where it's quickly and completely destroyed. After gastric bypass naloxone can be adopted by portions of the intestine that aren't served through the portal system, causing blood degrees of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.